Yes while capturing some imaging software that required the computer to be restarted. According to the following MS KB Article http://support.microsoft.com/?kbid=870904 ... "It is used by the Microsoft Software Update Services (SUS) 2.0 version of the Automatic Updates service is opened exclusively by the operating system. This folder was added in windows xp sp2."
Try to stop Windows Update Service (Automatic Updates) before packaging an msi. I found out that msi creation will get several errors if SMS (Microsoft System Management Server) and WUS services are running.