Hello, I am using Installshield 2013 I am trying to give "Users" group full permissions to the below registry key in 64 bit, the registry key is installing fine to 64 bit registry but when I try to give permissions in the msi using the "[SIZE=2]Custom Installshield Handling[/SIZE]" method getting the below errors at msi install HKEY_LOCAL_MACHINE\SOFTWARE\MyApp I made the components 64 bit and msi to 64 bit (template summary x64;1033) th reg key install in correct 64 bit location but at the time of applying the permissions getting the below errors it seems that there is a problem with "ISLockPermissions.dll" file Flexera said this issue already fixed in Installshield 2012 but still the issue is there we cant use "Custom Installshield Handling" for 64 bit registry permissions. InstallShield 21:18:22: Error extracting ISBEW64.exe from ISLockPermissions.dll .. .. InstallShield 21:18:22: Failed to initialize 64-bit helper, error 80070002 InstallShield 21:18:22: Failed to obtain 64-bit helper process for permission item 'MACHINE\Software\MyApp', error '80070002' InstallShield 21:18:22: Failed to apply permissions for object 'MACHINE\Software\MyApp', error 0x80070002 Error 27555. Error attempting to apply permissions to object 'MACHINE\Software\MyApp'. System error: The system cannot find the file specified. (-2147024894) MSI (s) (90!D8) [21:19:05:244]: Product: My Project Name-1 -- Error 27555. Error attempting to apply permissions to object 'MACHINE\Software\MyApp'. System error: The system cannot find the file specified. (-2147024894) InstallShield 21:19:05: Error returned from ApplyPermissionsItems: 0x00000643 CustomAction ISLockPermissionsInstall returned actual error code 1603 (note this may not be 100% accurate if translation happened inside sandbox) ... View more