The InstallShield Professional product line creates installation programs that don't use Microsoft's Windows Installer service (MSI), but instead use a different installation engine---if the vendor used InstallShield Professional, there's no MSI database involved.
InstallShield Developer, part of AdminStudio, does create MSI-based installation packages.
(The Repackager part of AdminStudio is for migrating non-MSI installers to MSI format, for better compatibility with Active Directory/Group Policy, and that sort of thing.)