If you want AdminStudio to connect to and publish anything into SCCM, then AdminStudio needs to have access to at least one user account that has the right permissions in SCCM. AdminStudio supports two methods to authenticate with AdminStudio

1. Windows Authentication
• The IT user running AdminStudio connects with their own Windows user account to SCCM
2. Server Authentication
• They use an existing or set up a new service account and share the credentials out among the IT users

In either user case above, the account provided to AdminStudio will need the Application Administrator Role assignment in SCCM.

Both authentication methods mentioned above are discussed as part of the help article Creating a New Distribution System Connection found in the AdminStudio 2019 R2 help here: https://helpnet.flexerasoftware.com/adminstudio2019r2sp1/adminstudio.htmhelplibrary/AMDistSettings_New.htm

(AdminStudio version and related help is current as of this posting. Please checkout the documentation for the latest version via the links found in the Community > AdminStudio main page )

Thanks @sanderson  for posting this!