To create a hybrid setup that will result in 32-bit and 64-bit packages, should I set the "64-Bit Component" property to "Yes" for all the 64-bit components, or leave it at "No"? The knowledge base article below doesn't clarify this.
If you are trying to create a hybrid project that can be built in either 32-bit or 64-bit form, then yes your 64-bit components should be marked as such. They also need to be masked out of your 32-bit build configuration through use of Release Flags on the features they are part of. The second half of this article is intended to describe this.